Rabu, 21 Desember 2016

Kunjungann

UNAIR NEWS – Pasca operasi facial cleft atau celah wajah tahap kedua pada Rabu (14/12), kondisi Tutik Handayani (17) berangsur pulih. Tutik, pasien celah wajah Rumah Sakit Universitas Airlangga, berbicara santai dengan awak media meskipun badannya masih sedikit lemas.


“Punggungku agak sakit,” ungkap Tutik.
Pada siang hari, Kamis (15/12), di waktu yang sama tim dokter yang menangani operasi Tutik dan Direktur Rumah Sakit Pendidikan UNAIR Prof. Dr. Nasronudin, dr., Sp.PD-KPTI, mengadakan konferensi pers perihal kondisi terkini Tutik. Indri Lakshmi Putri, dr., Sp.BP-RE (KKF) selaku dokter bedah plastik yang menangani Tutik mengatakan, operasi berjalan lancar meski waktu penanganan sempat terlambat.
“Harusnya kan operasi jam delapan, dan kenyataannya penanganan pukul sepuluh karena memang rangkaian biusnya lama. Jadi, dokter bius menyiapkan akses-akses pembuluh darah lebih besar daripada tangan untuk menghindari indikasi pendarahan,” ujar dokter Putri.
Pada operasi kedua, tim dokter melakukan pengambilan tulang wajah yang berlebihan pada sisi sebelah kiri wajah. Tulang tersebut digunakan untuk menutup celah wajah sebelah kanan. Pengambilan tulang dari pipi kiri juga diambil untuk membentuk bingkai mata Tutik yang sebelumnya agak turun.
Selain itu, tim dokter juga mengambil bagian tulang punggung untuk digunakan menutupi celah wajah. Sebanyak empat gigi Tutik juga dicabut karena dianggap tidak berfungsi. “Hasilnya, pipi Tutik yang mulanya sedikit kempes sekarang sudah dinaikkan,” tambah konsultan kraniofasial itu.
Pada bagian mata, tim dokter memasang conformer (bola mata palsu) pada sepasang mata untuk memberi kesan normal. “Untuk mata kiri keadaannya cukup menantang karena ada beberapa hal yang harus diperbaiki. Pertama, kelopaknya membalik ke atas, kemudian yang kedua tertarik ke bawah,” ujar Nurdin Zuhri, dr., Sp.M, selaku tim operasi.
“Yang kemarin kita lakukan dalam operasi tahap kedua adalah kita membalik kelopak matanya, kemudian kita bentuk celahnya untuk tempat conformer. Kita lapisi kulit dari bagian dalam bibir yang ditempatkan di kelopak mata untuk membantu agar anatomi kembali seperti semula,” tambah dokter Nurdin.
Dokter Putri kembali menambahkan, operasi yang berlangsung sekitar delapan jam ini berjalan lancar dan sesuai target. Ia dan timnya tidak mengalami kendala yang berarti. “Operasi selanjutnya akan dilakukan enam bulan lagi, tapi di tiga bulan ke depan, kita akan lakukan CT-Scan pada Tutik untuk konsolidasi awal,” tandas dokter Putri.
Rencananya, operasi tahap ketiga akan dilangsungkan enam bulan kemudian. Selama menunggu, Tutik akan kembali ke daerah asalnya, Lumajang, untuk menjalani rutinitas.
Yang kemarin kita lakukan dalam operasi tahap kedua adalah kita membalik kelopak matanya, kemudian kita bentuk celahnya untuk tempat conformer. Kita lapisi kulit dari bagian dalam bibir yang ditempatkan di kelopak mata untuk membantu agar anatomi kembali seperti semula,” tambah dokter Nurdin.
Dokter Putri kembali menambahkan, operasi yang berlangsung sekitar delapan jam ini berjalan lancar dan sesuai target. Ia dan timnya tidak mengalami kendala yang berarti. “Operasi selanjutnya akan dilakukan enam bulan lagi, tapi di tiga bulan ke depan, kita akan lakukan CT-Scan pada Tutik untuk konsolidasi awal,” tandas dokter Putri.
Rencananya, operasi tahap ketiga akan dilangsungkan enam bulan kemudian. Selama menunggu, Tutik akan kembali ke daerah asalnya, Lumajang, untuk menjalani rutinitas.
Pada siang hari, Kamis (15/12), di waktu yang sama tim dokter yang menangani operasi Tutik dan Direktur Rumah Sakit Pendidikan UNAIR Prof. Dr. Nasronudin, dr., Sp.PD-KPTI, mengadakan konferensi pers perihal kondisi terkini Tutik. Indri Lakshmi Putri, dr., Sp.BP-RE (KKF) selaku dokter bedah plastik yang menangani Tutik mengatakan, operasi berjalan lancar meski waktu penanganan sempat terlambat.

rESEARCH


Lungs anomaly detection by filtered back projection reconstruction method in electrical impedance tomography
a  Engineering Physics Program, Indonesia
b  Informatics Program, Institut Teknologi Bandung, Bandung, Indonesia c
  
Abstract
The electrical impedance tomography (EIT) is a promising imaging modality for early detection of lung disease. Several advantages of EIT imaging, such as save, simple and low cost. However, the better reconstruction method is still under investigated. The paper proposed filtered back projection to produce an anomaly image in the lungs. The method is applied to reconstruct an image from relative potential data of expiration and inspiration and also on normal lung and lung with anomaly. The simulation shows that the reconstruction method of filtered back projection from the relative potential data of expiration and inspiration have not been able to detect any anomalies, but from the relative potential data of normal lungs and lungs with anomaly is able to detect the presence and position of anomaly although have not been able to distinguish the size of the anomaly. © 2013 IEEE.

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Research


Non-HLA gene polymorphisms and their implications on dengue virus infection

a  Tropical and Infection Diseases Division, Internal Medicine Department, School of Medicine, Syiah Kuala University, Banda Aceh, Indonesia
b  Post-graduate Program, Immunology Department, Airlangga University, Surabaya, Indonesia 

Abstract
Exposure to the dengue virus (DENV) evokes a variety of genetically-controlled immunological responses. Genetic variants involved in viral entry, replication and innate immunity pathways play an important role in the causal pathway of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). Here we have reviewed implications of some genetic polymorphisms of the pathways related to DENV infection susceptibility, protection and severity. Large case-control studies examining a variety of single-nucleotide polymorphisms (SNPs) in a variety of genes have been performed in DENV patients in some countries. SNP gene candidates that have shown associations with DENV infection are mannose-binding lectin (MBL), interleukin (IL)-4, IL-6, IL-10, interleukin-1 receptor antagonist (IL-1RA), toll-like receptor 4 (TLR4), cytotoxic T-lymphocyte antigen 4 (CTLA-4), tumor necrosis factor (TNF)-α, transforming growth factor (TGF)-β1, Fcγ receptor II (FcγRII), vitamin D receptor (VDR), interferon (IFN)-γ, human platelet antigens (HPA), transporters associated with antigen processing (TAP), dendritic cell-specific ICAM3-grabbing non-integrin (DC-SIGN) and Janus kinase 1 (JAK1), although some of these genes failed to show statistical significance. Briefly, polymorphism in TNF-α, FcγRII, CTLA-4, TGF-β1, HPA, DC-SIGN, TAP and JAK1 genes has been associated with DHF/DSS development. Polymorphism in MBL2 gene was shown to be associated with thrombocytopenia and increased risk of DHF development. In contrary, polymorphism in VDR gene shows moderate associations with resistance to the most severe form of DHF. However, neutral associations have been reported for IL-4 promoters, IL-1RA, IFN-γ, IL-6, TLR4 and IL-10 gene polymorphism. In conclusion, there are strong evidences from several epidemiological studies indicating host genetic factors as important components in DENV infection susceptibility, protection and severity. © 2012.

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Research


Lungs anomaly detection by filtered back projection reconstruction method in electrical impedance tomography
a  Engineering Physics Program, Indonesia
b  Informatics Program, Institut Teknologi Bandung, Bandung, Indonesia c
  
Abstract
The electrical impedance tomography (EIT) is a promising imaging modality for early detection of lung disease. Several advantages of EIT imaging, such as save, simple and low cost. However, the better reconstruction method is still under investigated. The paper proposed filtered back projection to produce an anomaly image in the lungs. The method is applied to reconstruct an image from relative potential data of expiration and inspiration and also on normal lung and lung with anomaly. The simulation shows that the reconstruction method of filtered back projection from the relative potential data of expiration and inspiration have not been able to detect any anomalies, but from the relative potential data of normal lungs and lungs with anomaly is able to detect the presence and position of anomaly although have not been able to distinguish the size of the anomaly. © 2013 IEEE.

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PENELITIAN


Reduced-order model based on H∞-balancing for infinite-dimensional systems

a  Department of Mathematics, Faculty of Science and Technology, Universitas Airlangga, Kampus C Unair, Jl. Mulyorejo, Surabaya 60115, Indonesia
b  Department of Mathematics, Faculty of Mathematics and Natural Science, Institut Teknologi Bandung, Jl. Ganesa 10, Bandung, Indonesia 

Abstract
This paper presents a model reduction for unstable infinite dimen-sional system (A;B;C) using H∞-balancing. To construct H∞-balanced realization, we find a Lyapunov-balanced realizationof a normalized left-coprime factorization (NLCF) of the scaled system (A; βB;C). Next, we apply the new coordinate transformation to obtain yet another re-alization of NLCF system. This result is then translated to have the new scaled system (At; βBt;Ct) whichsimilar with (A; βB;C). Fur-thermore, it can be verified that the solutions of a control and ffilter H∞-Riccati operator equations of the system (At;Bt;Ct) are equal and diagonal. This implies that the system (At;Bt;Ct) is H∞-balanced re-alization of the system (A;B;C). Based on the small H∞-characteristic values, the state variables of the system (At;Bt;Ct) is truncated, to yield a reduced-order model of the system (A;B;C). To demonstrate the effectiveness of the proposed method, numerical simulations are ap-plied to Euler-Bernoulli beam equation.

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A malaria model with controls on mass treatment and insecticide
a  Department of Mathematics, Faculty of Science and Technology, Universitas Airlangga Kampus C Unair, Jl. Mulyorejo Surabaya 60115, Indonesia
b  Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia Kampus UI Depok, Depok 16424, Indonesia 

Abstract
In this paper we derive a mathematical model for malaria transmis-sion in population. We use controls on mass treatment and insecticide to reduce the number of infected hosts and infected vectors. The model considers human, larvae and mosquito populations. The host popula- tion is assumed constant, but the larvae and vector populations vary. First, we investigated the existence and stability of equilibria of the model without control based on the basic reproduction ratio. Then, the Pontryagins maximum principle is used to characterize the optimal control. The optimality system is derived and solved numerically for several scenarios. © 2013 Fatmawati and Hengki Tasman.

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